Table 2.
HPV, p53 and p16 status versus patients’ characteristics
| Treatment | HPVa | p | p16a | p | p53a | p | |||
|---|---|---|---|---|---|---|---|---|---|
| Negative | Positive | Negative | Positive | Negative | Positive | ||||
| Sex | |||||||||
| Female | 16 (21.3) | 3 (25.0) | 0.720 | 18 (16.7) | 5 (38.5) | 0.071 | 6 (16.2) | 17 (21.0) | 0.624 |
| Male | 59 (78.7) | 9 (75.0) | 90 (83.3) | 8 (61.5) | 31 (83.8) | 64 (79.0) | |||
| Age at diagnosis | |||||||||
| ≤ 60 years old | 39 (52.0) | 7 (58.3) | 0.763 | 51 (47.2) | 7 (53.8) | 0.772 | 14 (37.8) | 44 (54.3) | 0.115 |
| > 60 years old | 36 (48.0) | 5 (41.7) | 57 (52.8) | 6 (46.2) | 23 (62.2) | 37 (45.7) | |||
| Alcohol consumption | |||||||||
| ≤ 20 years | 19 (25.3) | 2 (16.7) | 0.722 | 21 (19.4) | 3 (23.1) | 0.720 | 7 (18.9) | 17 (21.0) | 0.813 |
| > 20 years | 56 (74.7) | 10 (83.3) | 87 (80.6) | 10 (76.9) | 30 (81.1) | 64 (79.0) | |||
| Tobacco consumption | |||||||||
| ≤ 20 years | 14 (18.7) | 5 (41.7) | 0.125 | 25 (23.1) | 1 (7.7) | 0.295 | 8 (21.6) | 18 (22.2) | 0.572 |
| > 20 years | 61 (81.3) | 7 (58.3) | 83 (76.9) | 12 (92.3) | 29 (78.4) | 63 (77.8) | |||
| Clinical stage | |||||||||
| I or II | 21 (29.2) | 2 (16.7) | 0.497 | 26 (26.0) | 3 (23.1) | 1.000 | 5 (14.3) | 23 (30.3) | 0.099 |
| III or IV | 51 (70.8) | 10 (83.3) | 74 (74.0) | 10 (76.9) | 30 (85.7) | 53 (69.7) | |||
| Histological grade | |||||||||
| Well differentiated | 11 (15.1) | 0 (0.0) | 0.442 | 13 (12.3) | 1 (7.7) | 0.912 | 7 (18.9) | 7 (8.9) | 0.264 |
| Moderately differentiated | 42 (57.5) | 9 (75.0) | 62 (58.5) | 9 (69.2) | 19 (51.4) | 49 (62.0) | |||
| Poorly differentiated | 20 (27.4) | 3 (25.0) | 31 (29.2) | 3 (23.1) | 11 (29.7) | 23 (29.1) | |||
| Surgery | |||||||||
| No | 58 (77.3) | 12 (100.0) | 0.112 | 95 (88.0) | 7 (53.8) | 0.006 | 31 (83.8) | 69 (85.2) | 1.000 |
| Yes | 17 (22.7) | 0 (0.0) | 13 (12.0) | 6 (46.2) | 6 (16.2) | 12 (14.8) | |||
| Chemoradiotherapy | |||||||||
| No | 18 (24.0) | 0 (0.0) | 0.140 | 24 (22.2) | 2 (15.4) | 0.803 | 7 (18.9) | 17 (21.0) | 0.871 |
| Chemo or Radio | 25 (33.3) | 6 (50.0) | 38 (35.2) | 4 (30.8) | 12 (32.4) | 29 (35.8) | |||
| Chemo and Radio | 32 (42.7) | 6 (50.0) | 46 (42.6) | 7 (53.8) | 18 (48.6) | 35 (43.2) | |||
| HPV | |||||||||
| Negative | – | – | – | 65 (85.5) | 9 (90.0) | 1.000 | 24 (88.9) | 47 (83.9) | 0.743 |
| Positive | – | – | 11 (14.5) | 1 (10.0) | 3 (11.1) | 9 (16.1) | |||
| p16a | |||||||||
| Negative | 65 (87.8) | 11 (91.7) | 1.000 | – | – | – | 34 (91.9) | 72 (88.9) | 0.751 |
| Positive | 9 (12.2) | 1 (8.3) | – | – | 3 (8.1) | 9 (11.1) | |||
| p53a | |||||||||
| Negative | 24 (33.8) | 3 (25.0) | 0.743 | 34 (91.9) | 72 (88.9) | 0.751 | – | – | – |
| Positive | 47 (66.2) | 9 (75.0) | 3 (8.1) | 9 (11.1) | – | – | |||
aThere are missing values
Entries in boldface are significantly different