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. 2017 Apr 20;8(42):71489–71499. doi: 10.18632/oncotarget.17288

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Copyright: © 2017 Yoo et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) Sk-Hep-1 migration rate after anti-CD44 or CVV treatment. Cellular migration was inhibited when anti-CD44 or CVV was treated. IgG and Tris was treated as control. (*p < 0.05) (B) The expression of CD44 and the EMT markers in virus-treated and anticancer drug-treated Sk-Hep-1 cells. CVV treatment (1 multiplicity of infection, MOI) shows greater attenuation in EMT expression as well as in CD44 expression, compared to the target agent sorafenib (6 μM). (C) CD44+ cell population in live or dead Sk-Hep-1 cell after CVV, WT, cisplatin or sorafenib treatment. CD44+ population from either live cell fraction or dead cell fraction was decreased after CVV treatment whereas CD44+ populations only from dead cells was decreased. *p < 0.0001 (live vs dead), **p < 0.0001 CVV, cancer-favoring engineered vaccinia virus; IgG, immunoglobulin G.