Table 2. Univariate Cox proportional hazards model for disease-free survival (DFS) and overall survival (OS).
| DFS | OS | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age, years | ||||||
| < 65 | — | — | ||||
| ≥ 65 | 1.009 | 0.659–1.841 | 0.714 | 0.934 | 0.530–1.644 | 0.812 |
| Gender | ||||||
| Male | — | — | ||||
| Female | 1.013 | 0.617–1.662 | 0.961 | 1.546 | 0.860–2.776 | 0.145 |
| Tumor location | ||||||
| Right | — | — | ||||
| Transverse | 0.816 | 0.309–2.155 | 0.681 | 0.789 | 0.267–2.334 | 0.669 |
| Left | 1.392 | 0.619–3.130 | 0.423 | 1.291 | 0.512–3.252 | 0.589 |
| Sigmoid colon | 1.251 | 0.718–2.176 | 0.431 | 1.145 | 0.614–2.135 | 0.671 |
| T stage | ||||||
| T1 | 0.494 | 0.119–2.049 | 0.331 | 0.988 | 0.299–3.259 | 0.984 |
| T2 | 0.203 | 0.063–0.660 | 0.006* | 0.394 | 0.138–1.130 | 0.083 |
| T3 | 0.484 | 0.284–0.827 | 0.004* | 0.521 | 0.280–0.966 | 0.019* |
| T4 | — | — | ||||
| N stage | ||||||
| N0 | — | — | ||||
| N1 | 5.887 | 3.025–11.456 | < 0.001* | 4.157 | 2.009–8.602 | < 0.001* |
| N2 | 15.914 | 7.781–32.545 | < 0.001* | 13.193 | 6.149–28.307 | < 0.001* |
| AJCC stage | ||||||
| I | — | — | ||||
| II | 1.108 | 0.305–4.027 | 0.877 | 0.667 | 0.201–2.215 | 0.508 |
| III | 6.823 | 2.097–22.199 | 0.001* | 3.401 | 1.184–9.771 | 0.023* |
| IV | 49.185 | 12.615–191.764 | < 0.001* | 40.074 | 11.257–142.668 | < 0.001* |
| Differentiation | ||||||
| High | — | — | ||||
| Moderate | 1.315 | 0.750–2.306 | 0.341 | 1.458 | 0.764–2.780 | 0.253 |
| Low | 3.577 | 1.885–6.786 | < 0.001* | 4.358 | 2.140–8.872 | <0.001* |
| Vascular invasion | ||||||
| Yes | 4.901 | 2.469–9.721 | < 0.001* | 4.638 | 2.152–9.997 | <0.001* |
| No | — | — | ||||
| IL-35 expression | ||||||
| Positive | — | — | ||||
| Weak | 2.598 | 1.194–5.653 | 0.011* | 2.117 | 0.862–5.196 | 0.102 |
| Negative | 6.118 | 3.004–12.462 | < 0.001* | 6.348 | 2.875–14.014 | <0.001* |
*P < 0.05 indicates a significant association among the variables.