Figure 5. MGr1-Ag/37LRP promotes PrP^C induced gastric cancer multi-drug-resistance by activation of Caspase 3 probably through PI3K/AKT pathway.

(A) and (B) Caspase 3 activation was examined by immunofluorescence staining and the fluorescence intensity was measured using high-content screening scanning. MGr1-Ag/37LRP siRNA significantly increased caspase 3 activation in SGC7901/PrP compared with the control group (*p < 0.05). SGC7901 was employed as a positive control. (C) and (D) Western blot results showed that pAKT were significantly decreased in SGC7901/PRP when transiently transfected with MGr1-Ag/37LRP siRNA (lane 3) compared to the siRNA control group (lane 2, p < 0.05).