Table 3. Pathological features and immunohistochemistry results of certain biomarkers of NENs.
| Clinical and Pathological features | Total distribution (N=2010) | Gastric cardiac NENs (N=234) | Gastric body NENs (N=309) | Rectal NENs (N=595) | Pancreatic NENs (N=633) | Other NENs (N=239) | P value |
|---|---|---|---|---|---|---|---|
| n (Positive rate %) | n (Positive rate %) | n (Positive rate %) | n (Positive rate %) | n (Positive rate %) | n (Positive rate %) | ||
| Vascular space involvement | 1390 (13.8) | 209 (22.0) | 252 (19.0) | 497 (5.2) | 258 (17.4) | 174 (15.5) | 0.000* |
| Perineural invasion | 1378 (5.2) | 207 (5.8) | 250 (6.8) | 493 (1.8) | 256 (9.0) | 172 (6.4) | 0.000* |
| Necrosis | 1391 (9.1) | 208 (13.9) | 249 (13.3) | 499 (3.8) | 266 (11.3) | 169 (9.5) | 0.000* |
| Cystic degeneration | 1368 (2.6) | 204 (1.5) | 241 (0.4) | 490 (0.8) | 266 (9.8) | 167 (1.2) | 0.000* |
| Synaptophysin | 1296 (90.0) | 168 (91.1) | 215 (89.3) | 410 (88.8) | 327 (93.3) | 176 (86.9) | 0.149 |
| Choromogranin A | 1243 (67.6) | 148 (62.8) | 192 (75.0) | 371 (52.3) | 376 (81.6) | 156 (65.4) | 0.000* |
| CD56 | 532 (79.7) | 94 (80.9) | 111 (75.7) | 143 (77.6) | 117 (89.7) | 67 (71.6) | 0.021* |
| Neuron-specific enolase | 612 (78.8) | 78 (65.4) | 99 (67.7) | 218 (85.3) | 135 (83.7) | 82 (79.3) | 0.000* |
| S-100 protein | 205 (41.0) | 26 (26.9) | 33 (45.5) | 64 (48.8) | 49 (34.7) | 33 (42.4) | 0.32 |
| CK(AE1/AE3) | 940 (79.1) | 122 (82.0) | 165 (86.1) | 300 (82.7) | 227 (70.5) | 126 (74.6) | 0.001* |
* Significantly different, using Mantel-Haenszel χ2 test or Fisher's exact tests.