Table 1. Metabolic stability of the peptides.
Human Liver Microsomes | Mouse Liver Microsomes | |||||
---|---|---|---|---|---|---|
Peptide | T1/2 (min) | % Remaining at 20 min | % Remaining at 60 min | T1/2 (min) | % Remaining at 20 min | % Remaining at 60 min |
P60 | N.D. | N.D. | N.D. | N.D. | N.D. | N.D. |
P60-2A | < 2.5 | 0 | 0 | < 2.5 | 0 | 0 |
CM-1215 | 5.30 | 6.20 | 0 | 8 | 12 | 0 |
CM-1315 | 61.7 | 48.7 | 46.1 | 63.8 | 62.7 | 47.7 |