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. 2017 May 9;8(42):71782–71796. doi: 10.18632/oncotarget.17710

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Copyright: © 2017 Guan et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) WX-132-18B competitively inhibited the binding of colchicine to tubulin. The inhibition rate is expressed as the percentage (%) of decreased fluorescence of the colchicine-tubulin complex. (B) The impact of compounds on the binding of BODIPY FL-vinblastine-tubulin complex. Values are mean±SD, n=3. (C) Limited proteolysis assay. Tubulin was digested with trypsin following preincubation with vehicle (0.1% dimethyl sulfoxide), 10 μM of colchicine, vincristine, and WX-132-18B. Tubulin treated with WX-132-18B showed patterns of proteolysis similar to those of colchicine.