Table 2. Univariate and multivariate analysis of factors associated with survival of 315 HCC patients.

	Overall survival
	Univariate analysis			Multivariate analysis
Variables	HR	95%CI	P Value	HR	95%CI	P Value
Age(year) (≥60 vs <60)	0.8958	0.6580–1.219	0.4871
Sex(female vs male)	0.6165	0.4450-0.9740	0.0521
Serum AFP(ng/ml) (≥20 vs <20)	1.167	0.8392-1.615	0.3671
HBV (no vs yes)	0.8942	0.5668-1.391	0.6071
Cirrhosis (present vs absent)	1.556	0.9808-2.204	0.0643
Tumor Number (single vs multiple)	0.5553	0.4206-0.8662	0.0069	0.743	0.465-1.188	0.215
Tumor size(cm)(≥5 vs <5)	1.987	1.454-2.640	< 0.0001	1.751	1.207-2.540	0.003
Tumor differentiation (I-II vs III-IV)	1.856	1.455-3.118	0.0001	1.432	1.012-2.025	0.043
TNM Stage (I-II vs III)	1.662	1.215-2.207	0.0014	1.448	1.027-2.040	0.034
Barx2 expression (low vs high)	2.049	1.412-2.596	< 0.0001*	1.659	1.148-2.398	0.007*

Abbreviations: HR:hazard ratio; CI:confidence interval; AFP:alpha-fetoprotein

*P<0.05.