Table 3. Cox proportional hazards analysis of the impact of investigative lymphocyte subsets on time to recurrence and overall survival in the entire cohort.
| TTR | OS | |||||
|---|---|---|---|---|---|---|
| n (events) | HR (95 % CI) | P | n (events) | HR (95 % CI) | P | |
| CD3+ | ||||||
| Univariable | ||||||
| Low | 59 | 1.00 | 59 | 1.00 | ||
| High | 87 | 0.58 (0.37-0.89) | 0.014 | 113 | 0.72 (0.50-1.03) | 0.075 |
| Multivariable | ||||||
| Low | 59 | 1.00 | 59 | 1.00 | ||
| High | 87 | 0.64 (0.40-1.04) | 0.070 | 113 | 0.86 (0.57-1.28) | 0.450 |
| CD8+ | ||||||
| Univariable | ||||||
| Low | 123 | 1.00 | 165 | 1.00 | ||
| High | 23 | 0.31 (0.12-0.75) | 0.010 | 6 | 0.11 (0.02-0.81) | 0.030 |
| Multivariable | ||||||
| Low | 123 | 1.00 | 165 | 1.00 | ||
| High | 23 | 0.30 (0.12-0.77) | 0.013 | 6 | 0.10 (0.01-0.73) | 0.023 |
| FoxP3+ | ||||||
| Univariable | ||||||
| Low | 52 | 1.00 | 166 | 1.00 | ||
| High | 95 | 0.44 (0.28-0.68) | <0.001 | 7 | 0.11 (0.02-0.80) | 0.029 |
| Multivariable | ||||||
| Low | 52 | 1.00 | 166 | 1.00 | ||
| High | 95 | 0.55 (0.34-0.89) | 0.015 | 7 | 0.24 (0.03-1.77) | 0.162 |
| NKp46+ | ||||||
| Univariable | ||||||
| Low | 60 | 1.00 | 138 | 1.00 | ||
| High | 80 | 0.65 (0.41-1.01) | 0.056 | 27 | 0.47 (0.27-0.83) | 0.009 |
| Multivariable | ||||||
| Low | 60 | 1.00 | 138 | 1.00 | ||
| High | 80 | 1.35 (0.81-2.23) | 0.246 | 27 | 0.69 (0.38-1.24) | 0.213 |
Classification and regression tree-derived prognostic cutoffs are used to define “low” and “high” in all analyses. TTR= time to recurrence, OS= overall survival, HR= hazard ratio. Multivariable analysis includes age, location, adjuvant treatment, T-stage, N-stage, M-stage, differentiation grade (high vs low), resection margin (R0, R1, R2).