Table 5. Cox proportional hazards analysis of overall survival in relation to high and low infiltration of T and NK cells stratified by B cell and plasma cell density.
| CD20+ | IGKC+ | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | Low | High | |||||||
| n | HR (95% CI) | n | HR (95% CI) | p for interaction | n | HR (95% CI) | n | HR (95% CI) | p for interaction | |
| Entire cohort | ||||||||||
| CD3+ | ||||||||||
| Low | 59 | 1.00 | 25 | 1.00 | 0.009 | 58 | 1.00 | 27 | 1.00 | 0.208 |
| High | 23 | 1.54(0.90-2.62) | 61 | 0.56(0.33-0.96) | 30 | 1.29(0.80-2.09) | 56 | 0.82(0.46-1.45) | ||
| CD8+ | ||||||||||
| Low | 55 | 1.00 | 30 | 1.00 | 0.041 | 56 | 1.00 | 30 | 1.00 | 0.078 |
| High | 27 | 1.48(0.89-2.48) | 56 | 0.69(0.41-1.15) | 32 | 1.49(0.93-2.40) | 53 | 0.77(0.44-1.33) | ||
| FoxP3+ | ||||||||||
| Low | 61 | 1.00 | 25 | 1.00 | 0.327 | 57 | 1.00 | 30 | 1.00 | 0.023 |
| High | 23 | 0.69(0.39-1.22) | 61 | 0.47(0.27-0.80) | 32 | 0.97(0.60-1.56) | 54 | 0.42(0.25-0.73) | ||
| NKp46+ | ||||||||||
| Low | 56 | 1.00 | 36 | 1.00 | 0.821 | 69 | 1.00 | 24 | 1.00 | 0.575 |
| High | 24 | 0.70(0.40-1.23) | 46 | 0.62(0.37-1.06) | 16 | 0.76(0.40-1.44) | 56 | 0.92(0.50-1.68) | ||
| Esophageal cancer | ||||||||||
| CD3+ | ||||||||||
| Low | 38 | 1.00 | 17 | 1.00 | 0.028 | 36 | 1.00 | 20 | 1.00 | 0.381 |
| High | 15 | 1.09 (0.55-2.16) | 24 | 0.37(0.18-0.78) | 16 | 0.96(0.50-1.85) | 24 | 0.61(0.28-1.33) | ||
| CD8+ | ||||||||||
| Low | 35 | 1.00 | 21 | 1.00 | 0.207 | 36 | 1.00 | 21 | 1.00 | 0.402 |
| High | 18 | 1.06(0.55-2.04) | 20 | 0.58(0.28-1.22) | 16 | 1.10(0.57-2.12) | 23 | 0.72(0.34-1.53) | ||
| FoxP3+ | ||||||||||
| Low | 38 | 1.00 | 14 | 1.00 | 0.818 | 33 | 1.00 | 20 | 1.00 | 0.112 |
| High | 17 | 0.49(0.24-1.00) | 27 | 0.57(0.27-1.19) | 20 | 0.84(0.45-1.57) | 25 | 0.38(0.17-0.82) | ||
| NKp46+ | ||||||||||
| Low | 37 | 1.00 | 19 | 1.00 | 0.514 | 42 | 1.00 | 15 | 1.00 | 0.151 |
| High | 15 | 0.40(0.18-0.87) | 21 | 0.60(0.29-1.27) | 10 | 0.37(0.14-0.94) | 27 | 0.93(0.41-2.10) | ||
| Gastric cancer | ||||||||||
| CD3+ | ||||||||||
| Low | 21 | 1.00 | 8 | 1.00 | 0.012 | 22 | 1.00 | 7 | 1.00 | 0.292 |
| High | 8 | 5.26(1.86-14.91) | 37 | 0.96(0.39-2.32) | 14 | 1.94(0.93-4.06) | 32 | 1.00(0.38-2.68) | ||
| CD8+ | ||||||||||
| Low | 20 | 1.00 | 9 | 1.00 | 0.009 | 20 | 1.00 | 9 | 1.00 | 0.063 |
| High | 9 | 4.36(1.63-11.63) | 36 | 0.84(0.36-1.96) | 16 | 2.12(1.01-4.45) | 30 | 0.68(0.28-1.65) | ||
| FoxP3+ | ||||||||||
| Low | 23 | 1.00 | 11 | 1.00 | 0.007 | 24 | 1.00 | 10 | 1.00 | 0.034 |
| High | 6 | 1.90(0.73-4.91) | 34 | 0.38(0.18-0.83) | 12 | 1.24(0.59-2.61) | 29 | 0.36(0.16-0.82) | ||
| NKp46+ | ||||||||||
| Low | 19 | 1.00 | 17 | 1.00 | 0.066 | 27 | 1.00 | 9 | 1.00 | 0.109 |
| High | 9 | 1.84(0.79-4.29) | 25 | 0.66(0.31-1.38) | 6 | 2.71(1.04-7.02) | 29 | 0.84(0.33-2.11) | ||
Prognostic cutoffs derived from the median number of immune cells are used to define “low” and “high” in all analyses. HR= hazard ratio. CI= confidence interval.