Table 2. Cox regression analysis for the association between serum exosomal miR-638 and OS of colon cancer patients.

Factors	Univariate analysis		Multivariate analysis
	HR(95%CI)	P-value	HR(95%CI)	P-value
Age (≥58 years)	1.23(0.78-1.93)	0.367	1.15(0.73-1.82)	0.542
Gender (Male)	1.04(0.66-1.63)	0.853	1.00(0.64-1.57)	0.999
TNM stage (III/IV)	2.25(1.30-3.90)	0.004	3.13(1.70-5.75)	<0.001
Tumor differentiation grade (Low)	1.47(0.92-2.34)	0.105	2.28(1.37-3.78)	0.001
Vascular infiltration	0.76(0.33-1.76)	0.528	0.99(0.41-2.41)	0.987
Lymph node metastasis	1.14(0.56-2.43)	0.278	1.87(1.04-3.49)	0.345
Liver metastasis	2.76(1.29-3.98)	0.007	3.13(1.70-5.75)	0.009
Low levels of serum exosomal miR-638	2.01(1.28-3.17)	0.003	1.90(1.20-3.91)	0.006