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. 2017 Aug 22;8(42):72363–72374. doi: 10.18632/oncotarget.20390

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Copyright: © 2017 Song et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) the methylation statuses of H19/Igf2 imprinting in PFFs derived from in vivo fertilized and cloned fetuses, (B) H19/Igf2 methylation levels in PFFs derived from in vivo fertilized and cloned fetuses, (C) the transcription of H19/Igf2 and genes related to the imprinting methylation maintenance in PFFs derived from in vivo fertilized and cloned fetuses. PFFs derived from the morphologically abnormal cloned fetuses displayed the hypomethylated H19/Igf2 imprinting, upregulated H19 transcription and downregulated expression of Igf2 and imprinting methylation maintenance related genes. con represented PFFs derived from the in vivo fertilized fetuses, a1, a2, a3 and a4 represented PFFs derived from the morphologically abnormal cloned fetuses, and n1 and n2 represented PFFs derived from the morphologically normal cloned fetuses, respectively. Black or white circles indicate methylated or unmethylated CpG sites, respectively. ^a–dValues for a given gene with different superscripts differ significantly (P < 0.05).