Table 4. IC50 values and RIs of Bel7402/5-FU cells treated with different chemotherapeutic agents in the presence or absence of Ubenimex for 24 h.
| Drugs | Bel7402 IC50(μmol/L) | Bel7402 /5-FU | Bel7402 /5-FU + Ubenimex | ||
|---|---|---|---|---|---|
| IC50(μmol/L) | RI | IC50(μmol/L) | RI | ||
| 5-fluorouracil | 39.2±1.2 | 456.2±4.1 | 11.4±0.4 | 186.2±2.5** | 3.9±0.2** |
| Cisplatin | 4.0±0.9 | 100.9±6.2 | 30.5±7.2 | 52.3±1.9** | 11±2.9** |
| Oxaliplatin | 8.5±0.3 | 120.3±3.2 | 14.1±0.3 | 60.5±1.1** | 7.0±0.4** |
IC50 values and RI were determined by the CCK-8 method. Data are expressed as means ±SD. **P<0.01 versus Cisplatin; 5-fluorouracil and Oxaliplatin without Ubenimex.