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. 2017 Aug 18;8(42):72773–72787. doi: 10.18632/oncotarget.20347

Figure 5. Adjustment of H3R117 mono-ADP-ribosylation or P300 affects β-catenin, c-myc and cyclinD1.

Figure 5

(A & B) Effects on the change of protein expression level in each LOVO cells group. Expression of c-myc and cyclin D1 in the LOVO cells groups showed a significant decrease in the mutant groups compared with the control LOVO groups (*p<0.05, ** p<0.01). (C & D) Proteins were extracted from nude mouse transplanted tumor tissues. The results of protein expression in vitro were in accordance with in vivo (*P<0.05). (E&F) Western blots showed that the expressions of c-myc and cyclinD1 in the mutants treated with CTBP groups were significantly increased compared with the mutant groups without CTBP (*p<0.05,** p<0.01).