Table 3. Summary of results in the association of GSTP1 polymorphism with tumor response and overall survival.
| GSTP1 Genotype | No. of studies | Tumor response | No. of studies | Overall survival | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of patients | OR (95 % CI) | P value | P of heterogeneity | I2 (%) | No. of patients | HR (95 % CI) | P value | P of heterogeneity | I2 (%) | |||||
| GA vs. AA | Overall | 15 | 2941 | 1.32 (0.97–1.80) | 0.073 | 0.001 | 63.2 | 13 | 4274 | 1.14 (0.97–1.33) | 0.106 | 0.328 | 11.7 | |
| Ethnicity | East Asian | 12 | 2684 | 1.38 (0.99–1.92) | 0.058 | 0.001 | 64.6 | 8 | 3059 | 1.10 (0.90–1.33) | 0.347 | 0.289 | 17.9 | |
| South Asian | 2 | 217 | 1.43 (0.46–4.43) | 0.533 | 0.054 | 73.1 | 2 | 347 | 1.53 (0.78–2.99) | 0.218 | 0.739 | 0.0 | ||
| Mixed descent | 1 | 40 | 0.38 (0.10–1.15) | 0.158 | NA | NA | 3 | 868 | 1.19 (0.78–1.81) | 0.423 | 0.132 | 50.6 | ||
| Sample size | Large | 14 | 2901 | 1.38 (1.02–1.88) | 0.038 | 0.001 | 63.1 | 12 | 4179 | 1.11 (0.94–1.31) | 0.231 | 0.306 | 14.1 | |
| Small | 1 | 40 | 0.38 (0.10–1.45) | 0.143 | NA | NA | 1 | 95 | 1.37 (0.88–2.13) | 0.163 | NA | NA | ||
| Overall | 14 | 2901 | 1.29 (0.79–2.13) | 0.312 | 0.000 | 71.6 | 12 | 4149 | 0.94 (0.56–1.57) | 0.814 | 0.000 | 80.3 | ||
| Ethnicity | East Asian | 12 | 2684 | 1.19 (0.69–2.03) | 0.531 | 0.000 | 73.7 | 8 | 3059 | 1.08 (0.57–2.06) | 0.806 | 0.000 | 85.7 | |
| GG vs. AA | South Asian | 2 | 217 | 2.41 (0.88–6.58) | 0.086 | 0.467 | 0.0 | 1 | 222 | 0.30 (0.03–2.99) | 0.305 | NA | NA | |
| Mixed descent | NA | NA | NA | NA | NA | NA | 3 | 868 | 0.72 (0.26–2.00) | 0.525 | 0.052 | 66.2 | ||
| GA + GG vs. AA (dominant model) | Sample size | Large | 14 | 2901 | 1.29 (0.79–2.13) | 0.312 | 0.000 | 71.6 | 11 | 4054 | 0.89 (0.51–1.57) | 0.692 | 0.000 | 81.6 |
| Small | NA | NA | NA | NA | NA | NA | 1 | 95 | 1.51 (0.75–3.02) | 0.246 | NA | NA | ||
| Overall | 15 | 2941 | 1.37 (0.97–1.94) | 0.074 | 0.000 | 76.3 | 3 | 1048 | 1.74 (1.32–2.30) | < 0.001 | 0.140 | 49.2 | ||
| Ethnicity | East Asian | 12 | 2684 | 1.43 (0.97–2.10) | 0.068 | 0.000 | 78.6 | 1 | 420 | 2.53 (1.60–4.03) | NA | NA | NA | |
| South Asian | 2 | 217 | 1.58 (0.55–4.56) | 0.399 | 0.056 | 72.6 | NA | NA | NA | NA | NA | NA | ||
| Mixed descent | 1 | 40 | 0.38 (0.10–1.15) | 0.158 | NA | NA | 2 | 628 | 1.41 (0.99–2.00) | 0.053 | 0.956 | 0.0 | ||
| Sample size | Large | 14 | 2901 | 1.45 (1.02–2.06) | 0.040 | 0.000 | 77.0 | 2 | 953 | 1.98 (1.14–3.45) | 0.015 | 0.152 | 51.2 | |
| Small | 1 | 40 | 0.38 (0.10–1.45) | 0.143 | NA | NA | 1 | 95 | 1.40 (0.92–2.12) | 0.100 | NA | NA | ||
| GG vs. AA+GA (recessive model) | Overall | 14 | 2901 | 1.05 (0.70–1.57) | 0.829 | 0.000 | 66.2 | NA | NA | NA | NA | NA | NA | |
| Ethnicity | East Asian | 12 | 2684 | 0.97 (0.63–1.48) | 0.872 | 0.000 | 68.7 | NA | NA | NA | NA | NA | NA | |
| South Asian | 2 | 217 | 2.07 (0.78–5.47) | 0.143 | 0.797 | 0 | NA | NA | NA | NA | NA | NA | ||
| Mixed descent | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||
| Sample size | Large | 14 | 2901 | 1.05 (0.70–1.57) | 0.829 | 0.000 | 66.2 | NA | NA | NA | NA | NA | NA | |
| Small | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ||
| Allele model (G vs. A) | Overall | 15 | 2941 | 1.26 (0.93–1.70) | 0.134 | 0.000 | 82.2 | 2 | 601 | 1.32 (0.47–3.74) | 0.601 | 0.004 | 87.7 | |
| Ethnicity | East Asian | 12 | 2684 | 1.28 (0.91–1.79) | 0.156 | 0.000 | 84.6 | 2 | 601 | 1.32 (0.47–3.74) | 0.601 | 0.004 | 87.7 | |
| South Asian | 2 | 217 | 1.54 (0.76–3.10) | 0.231 | 0.101 | 62.9 | NA | NA | NA | NA | NA | NA | ||
| Mixed descent | 1 | 40 | 0.38 (0.10–1.45) | 0.143 | NA | NA | NA | NA | NA | NA | NA | NA | ||
| Sample size | Large | 14 | 2901 | 1.31 (0.96–1.78) | 0.089 | 0.000 | 83.1 | 2 | 601 | 1.32 (0.47–3.74) | 0.601 | 0.004 | 87.7 | |
| Small | 1 | 40 | 0.38 (0.10–1.45) | 0.143 | NA | NA | NA | NA | NA | NA | NA | NA | ||
GSTP1 glutathione S-transferase P1, OR odds ratio, CI confidence interval, HR hazard ratio, NA not available.