Table 1. Characteristics of studies.
| Author (year) | Study design | Enrollment period | Ethnicity | No. of patients | Mean Age (SD) | Definition of dementia | Study period | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total cohort (case/control) | Cases studied | Controls studied | Cases | Controls | Type | Code | Index date | Follow-up duration (year) | Lagging time (month) | ||||
| Kao, et al. (2016) | Retrospective cohort | 2001–2008 | Asian | 1,481/1,314 | 755 | 559 | 74.2 (7.9) | 69.3 (10.1) | All types | 290.0–290.4, 294.1, 331.0–331.2, or 331.82 | The date of the first ambulatory care visit | 5 | - |
| Chung, et al. (2016) | Retrospective cohort | 2001–2008 | Asian | 1,481/1,335 | 768 | 567 | 74.2 (8.0) | 69.5 (10.2) | Alzheimer disease | 331.0 | The date of the first ambulatory care visit | 5 | - |
| Nead, et al. (2016) | Retrospective cohort | 1994–2013 | White or others | 18,218/16,888 | 2397 | 14491 | 70.9 (10.8) | 66.7 (10.5) | Alzheimer disease | 331.0 | The date of the first ambulatory care visit | 2.7 | 6 |
| Nead, et al. (2016)a | Retrospective cohort | - | White or others | 18,218/6,671 | 1292 | 5379 | 78.9 (6.9) | 77.5 (6.5) | Alzheimer disease | 331.0 | The date of the first ambulatory care visit | 2.7 | 6 |
| Nead, et al. (2017) | Retrospective cohort | 1994–2013 | White or others | 9,455/9,272 | 1826 | 7446 | 69.9 (11.0) | 66.2 (10.8) | All types | 290.0–290.9, 331.0–331.2, or 294.1–294.21 | The date of the first ambulatory care visit | 3.4 | 6 |
| Khosrow-Khaver, et al. (2017) | Retrospective cohort | - | White or others | 52,599/30,903 | 15310 | 15393 | 72.8 (8.3) | 68.7 (9.0) | All types | - | 1 year after the date of the first prescription, or surgery date of the bilateral crhiectomy | 2.3 | 12 |
| Jhan, et al. (2017) | Retrospective cohort | - | Asian | 28,178/24,360 | 15959 | 8401 | 75.48 (6.92) | 74.28 (7.26) | Alzheimer disease | 290.1–290.3, 294.1–294.2, and 331.0 | The date of the first ambulatory care visit | 4 | 3 |
a, publicated on Scientific Reports.