Table 2. Results of the meta-analysis.
| Author (year, journal) | Incidence rate per 1000 (95% CI) | IRR | Crude HR | Adjusted HR | ||||
|---|---|---|---|---|---|---|---|---|
| In cases | In controls | Ratio (95% CI) | p-value | Ratio (95% CI) | p-value | Ratio (95% CI) | p-value | |
| Dementia including Alzheimer | ||||||||
| Kao, et al. (2016) | 2.36 (1.22–4.55) | 1.86 (0.79–4.39) | 1.27 (0.43–3.74) | 0.90 (0.62–1.31) | 1.21 (0.82–1.79) | |||
| Chung, et al. (2016) | 3.44 (2.00–5.90) | 1.69 (0.69–4.14) | 2.02 (0.71–5.73) | 2.05 (0.64–6.52) | 1.76 (0.55–5.59) | |||
| Nead, et al. (2016) | - | - | - | - | 1.66 (1.06–2.61) | |||
| Nead, et al. (2016)a | 2.90 (1.56–5.36) | 1.90 (1.31–2.76) | 1.53 (0.74–3.14) | - | 2.04 (1.23–3.40) | |||
| Nead, et al. (2017) | 7.89 (5.97–10.44) | 3.50 (2.84–4.31) | 2.26 (1.69–3.20) | 3.00 (2.33–3.87) | 2.21 (1.71–2.85) | |||
| Khosrow-Khaver, et al. (2017) | 7.40 (6.55–8.35) | 4.40 (3.76–5.15) | 1.68 (1.38–2.05) | - | 1.02 (0.87–1.19) | |||
| Jhan, et al. (2017) | - | - | - | 1.96 (1.55–2.48) | 1.84 (1.32–2.57) | |||
| Overall by random effect model | 4.67 (3.10–7.04) | 2.81 (1.96–4.03) | 1.78 (1.51–2.10) | < 0.001 | 1.80 (1.05–3.10) | 0.032 | 1.59 (1.16–2.18) | 0.004 |
| Heterogeneity, I2 (%) | 84.9% (66.3–93.2%) | 82.3% (59.2–92.3%) | 0.0% (0.0–69.3%) | 0.606 | 89.1% (74.7–95.3%) | < 0.001 | 82.2% (64.5–91.1%) | < 0.001 |
| Alzheimer disease only | ||||||||
| Chung, et al. (2016) | 3.44 (2.00–5.90) | 1.69 (0.69–4.14) | 2.03 (0.71–5.77) | 2.05 (0.64–6.52) | 1.76 (0.55–5.59) | |||
| Nead, et al. (2016) | - | - | - | - | 1.66 (1.06–2.61) | |||
| Nead, et al. (2016) | 2.90 (1.56–5.36) | 1.90 (1.31–2.76) | 1.53 (0.74–3.14) | - | 2.04 (1.23–3.40) | |||
| Jhan, et al. (2017) | - | - | - | 1.96 (1.55–2.48) | 1.84 (1.32–2.57) | |||
| Overall by random effect model | 3.19 (2.13–4.79) | 1.87 (1.32–2.64) | 1.67 (0.92–3.03) | 0.09 | 1.96 (1.56–2.47) | < 0.001 | 1.83 (1.45–2.30) | < 0.001 |
| Heterogeneity, I2 (%) | 0.0% (NA) | 0.0% (NA) | 0.0% (NA) | 0.656 | 0.0% (NA) | 0.941 | 0.0% (0.0–0.0%) | 0.949 |
NA, not available; IRR, incidence rate ratio; HR, hazard ratio; CI, confidence interval.
a, publicated on Scientific Reports.