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. 2017 Apr 20;8(42):73240–73257. doi: 10.18632/oncotarget.17291

Figure 1. DNA damage repair and synthetic lethality.

Figure 1

Single-strand breaks need PARP for DNA repair, so inhibiting PARP will lead to double-stand breaks. In turn, double strand breaks need ATM/ATR, BRCA1 and BRCA2 for repair, so mutations or inhibition of these will lead to cell death.