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. Author manuscript; available in PMC: 2018 Sep 28.
Published in final edited form as: Nature. 2017 Sep 20;549(7673):523–527. doi: 10.1038/nature24016

Extended Data Figure 2. ApoE4 leads to more severe neuronal loss in the CA1 region of hippocampus in 9-month old P301S mice.

Extended Data Figure 2

a, Representative images of 9-month old TE mouse brain stained with cresyl violet. b, Thickness of the CA1 pyramidal neuronal layer (WT: n=7, TE2: n=14, TE3: n=11, TE4: n=17, TEKO: n=16). Data expressed as mean ± SEM, One-way ANOVA with Tukey’s post hoc test (two-sided). c, Correlation between CA1 neuronal layer thickness and hippocampal volume. N=62 biologically independent animals. Pearson correlation analysis (two-sided), p<0.0001, r2=0.35. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.