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. Author manuscript; available in PMC: 2018 Sep 28.
Published in final edited form as: Nature. 2017 Sep 20;549(7673):523–527. doi: 10.1038/nature24016

Extended Data Figure 8. Possession of ε4 allele accelerates the rate of disease progression in AD patients.

Extended Data Figure 8

Disease progression rate in a cohort of 592 CSF biomarker confirmed individuals with symptomatic AD from two different longitudinal studies, the Knight Alzheimer’s Disease Research Center (ADRC) at Washington University and the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Data generated based on the Clinical Dementia Rating Sum of Boxes (CDR-SB) scores. Possession of the ε4 allele significantly accelerated disease progression (p=0.02), with one ε4 allele increasing progression rate by 14% and two ε4 alleles increasing the rate by 23% compared to non-carriers (lineal mixed model, two-sided).