Table 1.

Association between time-varying physical activity and change in physical function using mixed effects linear regression

Physical function measure	Physical activity (MET- min/wk)a	Model 1 β (95% CI)	Model 2 β (95% CI)	Model 3 β (95% CI)
Grip strength (kg)
	< 100	Ref.	Ref.	Ref.
	100 to < 500	0.31 (0.05, 0.57)	0.28 (0.01, 0.54)	0.29 (0.02, 0.55)
	500 to < 1200	0.32 (0.05, 0.59)	0.25 (–0.03, 0.53)	0.25 (–0.03, 0.54)
	≥ 1200	0.53 (0.22, 0.84)	0.49 (0.17, 0.81)	0.48 (0.15, 0.80)
Chair stands (n)
	< 100	Ref.	Ref.	Ref.
	100 to < 500	0.20 (0.12, 0.28)	0.14 (0.06, 0.22)	0.14 (0.06, 0.23)
	500 to < 1200	0.37 (0.28, 0.45)	0.29 (0.21, 0.38)	0.28 (0.19, 0.37)
	≥ 1200	0.45 (0.35, 0.55)	0.36 (0.26, 0.47)	0.35 (0.25, 0.46)
Gait speed (m/s)
	< 100	Ref.	Ref.	Ref.
	100 to < 500	0.02 (0.01, 0.04)	0.02 (0.01, 0.03)	0.02 (0.01, 0.03)
	500 to < 1200	0.05 (0.04, 0.06)	0.04 (0.03, 0.05)	0.04 (0.02, 0.05)
	≥ 1200	0.07 (0.06, 0.08)	0.06 (0.04, 0.07)	0.06 (0.04, 0.07)

CI, confidence interval

^aSedentary (<100); Low (100 to < 500); Moderate (500 to < 1200); High (≥1200)

Model 1 adjusted for age at menopause, and baseline physical function measure

Model 2 further adjusted for race/ethnicity, education, current employment, alcohol use, smoking, BMI, depression, and clinical trial arm(s)

Model 3 further adjusted for history of hypertension, diabetes, cardiovascular disease, and arthritis