Table 1.
NRPs |
Expression |
Functions | Related diseases | Reference | |
Immune cells | Cellular context | ||||
NRP1 | Dendritic cells (DCs)
|
|
|
||
|
|
||||
|
|
|
|||
|
|
(156) | |||
T cells
|
|
(51, 179) | |||
|
|
|
|||
|
|
|
|||
|
|
|
|
||
|
|
(57, 58) | |||
|
|
|
(56) | ||
|
|
(264–266) | |||
|
|
(264–266) | |||
NRP2 | DCs
|
|
|||
Macrophages/microglia
|
|
(136) | |||
|
|
|
(154, 155) | ||
|
|
(153) | |||
|
Not known | (136, 151) | |||
Osteoclasts/osteoblasts |
|
|
|||
T cells
|
|
(249) | |||
|
Not known |
|
(260) | ||
|
|
|
Published abstract, ATC, 2015 | ||
|
|
|
Published abstract, ATC, 2015 | ||
|
|
(264–266) | |||
|
|
(264–266) |
NRPs, neuropilins; NRP1, neuropilin-1; NRP2, neuropilin-2; Sema3A, Semaphorin 3A; Tfh, T follicular helper; HTLV, human T-cell leukemia virus; TIDCs, tumor-infiltrating DCs; TAM, tumor-associated macrophage; EAE, experimental autoimmune encephalomyelitis; NKT, natural killer T; T-ALL, T-cell acute lymphoblastic leukemia; T-LBL, T-cell lymphoblastic lymphoma; iNKT, invariant natural killer T; GVHD, graft-versus-host disease; Treg, regulatory T cell.