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. 2017 Oct 10;8:782. doi: 10.3389/fphys.2017.00782

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Copyright © 2017 Lin, Zeng, Gao, Gu, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of NaHS or PAG on PLA-induced atherosclerosis in LCA. Representative light microscopy images of hematoxylin and eosin-stained (A) or Masson trichrome-stained (D) LCA cross sections were taken from sham-operated mice with saline, PLA mice with NaHS, PLA mice with PAG, or PLA mice with NaHS and MLN (intervention with MLN-4760 for 14 days). Scale bar for histological images = 100 μm. Lesion area of intima (B), intima/media ratio (C) and collagen deposits (E) in the neointimal hyperplasia in LCA were measured as described in Materials and Methods. Results shown are the mean ± SEM (n = 6 animals in each group). ^*P < 0.05 for the comparison between sham+saline and PLA+saline. ^**P < 0.05 for the comparison between PLA+saline and PLA+NaHS. ^***P < 0.05 for the comparison between PLA+saline and PLA+PAG. ^#P < 0.05 for the comparison between PLA+NaHS and PLA+NaHS+MLN.