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. 2017 Oct 10;8:714. doi: 10.3389/fphar.2017.00714

FIGURE 1.

FIGURE 1

Locomotor Measurements. Mean ± SEM of baseline locomotor measurements during exposure to (A) NaCl (n = 24) vs BD 1063 [3 mg/kg (n = 8) or 10 mg/kg (n = 8)] and (B) NaCl (n = 24) vs Siramesine [0.3 mg/kg (n = 8) or 1 mg/kg (n = 8)]. BD 1063 had no effect on baseline locomotor activity, whereas Siramesine significantly attenuated it at 5, 20, and 25 min. (C) BD 1063 mitigates acute cocaine-induced hyperlocomotion in the last half of the 30-min tracking interval. (D) Siramesine also attenuated the acute cocaine-induced increase in locomotor activity as designated by significance in the two-way ANOVA. Locomotor measurements from NaCl-treated control mice were pooled and represented in both graphs. #,∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. Two-way ANOVA followed by Bonferroni’s post hoc test.