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. Author manuscript; available in PMC: 2018 Sep 17.
Published in final edited form as: Neuroscience. 2017 Jul 17;359:119–129. doi: 10.1016/j.neuroscience.2017.07.020

Figure 6. AMPK activators do not effect wound healing in response to incision.

Figure 6

All Animals received a plantar incision on the left hindpaw. Skin from the left hindpaw was excised 3 and 7 days after plantar incision and wound healing and closure was assessed using Hematoxylin & Eosin (H & E) staining. A) Resveratrol (10 μg) or vehicle was injected in the left hind paw on the day of the surgery and 1-day post surgery. There was no difference in wound size between the resveratrol and vehicle treated groups on Day 3. The wound was completely closed by Day 7 in both vehicle and resveratrol groups. B) Metformin (200 mg/kg) or vehicle was injected systemically for 4 consecutive days, starting 2 days prior to surgery, the day of surgery, and 1-day post surgery. No differences were noted in the wound size between the metformin and vehicle treated groups on Day 3. The wound was completely closed by Day 7 in animals from groups receiving vehicle or metformin. Differences between groups were assessed by two tailed student’s t-test. (N = 6 per group).