Table 3.
Weighted Multivariable Logistic Regression Models for Factors Related to Preterm Delivery in (A) HIV-Exposed-Uninfected and HIV-Unexposed-Uninfected Infants combined and (B) HIV-Exposed-Uninfected Infants onlya
| Variable | (A) HEU and HUUb Combined | (B) HEU Onlyc | ||
|---|---|---|---|---|
| aOR (95% CI) | P Valued | aOR (95% CI) | P Value | |
| HIV exposure status | ||||
| HEU | 1.2 (1.0–1.5) | .04 | ---- | ---- |
| HUU | Ref | |||
| ARV | ---- | .04* | ||
| Preconception ART | 1.7 (1.1–2.5) | .02 | ||
| ZDV | 1.4 (0.9–2.0) | .11 | ||
| None | 1.9 (1.1–3.1) | .01 | ||
| Postconception ART | Ref | |||
| Syphilis serology | ||||
| Positive | 0.7 (0.4–1.2) | .22 | 0.7 (0.3–1.3) | .22 |
| Negative | Ref | Ref | ||
| Tuberculosis | ||||
| Yes | 1.1 (0.7–1.9) | .65 | 1.1 (0.5–2.3) | .83 |
| No | Ref | Ref | ||
| Maternal age, years | .08* | .08* | ||
| 20–25 | 0.9 (0.7–1.1) | .36 | 1.5 (0.7–3.2) | .31 |
| 26–29 | 0.9 (0.7–1.3) | .63 | 1.5 (0.7–3.5) | .35 |
| 30–35 | 0.7 (0.5–0.9) | .02 | 1.0 (0.5–2.3) | .94 |
| >35 | 1.0 (0.6–1.4) | .79 | 2.0 (0.9–4.6) | .11 |
| <20 | Ref | Ref | ||
| Parity | .20* | .08* | ||
| 2–3 | 0.8 (0.7–1.0) | .06 | 0.7 (0.4–0.9) | .02 |
| 4+ | 0.9 (0.6–1.2) | .40 | 0.7 (0.4–1.2) | .14 |
| 1 | Ref | Ref | ||
| Maternal education | ||||
| ≤ grade 7 | 1.4 (1.1–1.7) | <.01 | 1.1 (0.8–1.6) | .62 |
| > grade 7 | Ref | Ref | ||
| ANC visits | ||||
| +5 | 0.7 (0.6–0.9) | <.01 | 0.7 (0.5–1.0) | .08 |
| 1–5 | Ref | Ref | ||
| Household socio-economic quintile | <.01* | .02* | ||
| Poorest | 1.7 (1.2–2.5) | <.01 | 3.0 (1.3–6.8) | <.01 |
| Second | 1.2 (0.9–1.7) | .26 | 1.7 (0.7–3.8) | .24 |
| Third | 1.3 (1.0–1.8) | 1.00 | 2.6 (1.2–5.9) | .02 |
| Fourth | 1.1 (0.8–1.5) | .68 | 2.1 (0.9–4.4) | .07 |
| Least poor | Ref | Ref | ||
| Household food insecurity | ||||
| Yes | 0.8 (0.6–1.0) | .07 | 1.0 (0.6–1.5) | .82 |
| No | Ref | Ref | ||
| Infant race | <.01* | .41* | ||
| Colored | 1.7 (1.3–2.3) | <.01 | 1.4 (0.7–2.7) | |
| Other | 1.3 (0.5–3.4) | .56 | ---- | |
| Black | Ref | Ref | ||
| Infant gender | ||||
| Male | 0.9 (0.8–1.0) | .12 | 1.1 (0.8–1.5) | .55 |
| Female | Ref | Ref | ||
Abbreviations: ANC, antenatal care; aOR, adjusted odds ratio; ART, antiretroviral therapy; ARV, antiretroviral drug; CI, confidence interval; HEU, HIV-exposed-uninfected; HUU, HIV-unexposed; Ref, reference category; ZDV, Zidovudine.
aThe values in the models are aOR (95% CI).
bModel included 6214 HIV-exposed and -unexposed infants.
cModel included 1839 HIV-exposed-uninfected infants.
dExcept for the asterisk below, the P values in this table are t test P values. The 5% significance level was used in all analyses.
*This P value is derived from the joint hypothesis testing adjusted Wald test.