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Comparison of MLM stability between paroxetine and GSK180736A analogs
 | |||
|---|---|---|---|
| R = | Name | Scaffold | t1/2 in MLM (min) |
| N/A | 2 | N/A | 1.91 |
| H | 3 | B | 20.6 |
| H | Paroxetine | A | 24.3 |
 |
14ah | A | 36.4 |
| 15 | B | 3.37 | |
 |
14ag | A | 45.9 |
| 16 | B | 3.46 | |
 |
14ai | A | 24.9 |
| 4 | B | 3.82 | |
 |
14ak | A | 3.15 |
| 17 | B | 11.32 | |
 |
14as | A | 7.0 |
 |
14au | A | 10.3 |
