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. Author manuscript; available in PMC: 2018 Apr 13.
Published in final edited form as: J Med Chem. 2017 Mar 29;60(7):3052–3069. doi: 10.1021/acs.jmedchem.7b00112

Table 3.

In Vivo Exposure Following IP Administration to Mice*

plasma (µM) AUC 0 – 7hobs
(hr*µM)
Compound (dose) 30 min 2 h 4 h 7 h
2 (10 mg/kg) 1.83 0.032 0.005 0.006 1.90
14as (10 mg/kg) 2.71 1.44 0.27 0.043 5.97
*

CD-1 mice were injected intraperitoneally with a single indicated dose. The data shown are mean values from 3 mice at each time point.