Skip to main content
. Author manuscript; available in PMC: 2018 Jun 9.
Published in final edited form as: Science. 2017 Jun 9;356(6342):1084–1087. doi: 10.1126/science.aaf7497

Fig. 3. BIA 10-2474, but not PF04457845, causes substantial alterations in lipid metabolism in human cortical neurons.

Fig. 3

(A, B) Cortical neurons were treated with DMSO (A, B), BIA 10-2474 (50 μM) (A) or with PF04457845 (1 μM) (B) and analyzed by MS-based lipidomics after 48 h. X-axis denotes fold change of lipid species in the inhibitor-treated cells vs DMSO-treated cells. Lipidomic data are presented as a volcano plot and lipids with a fold change (FC) threshold of ≥1.20 or ≤0.80 and Benjamini–Hochberg false discovery rate (FDR) ≤ 25% are represented by colored circles distinguished by lipid class. Data represent average values from at least two independent experiments.