Table 1.

Antigen selection and presentation.

Antigen/APC	Advantage	Disadvantage
Whole virus/viral lysate	Potent antigen	Live virus, lengthy production time
Whole proteins	Readily available	Less potent antigen
Viral vectors	Reproducible	Lengthy production time
Peptide/peptide mixtures	Reproducible, standardized, readily available	Need identified immunodominant epitopes
Dendritic cells	Potent stimulators	Limited cell numbers, difficult to isolate
Monocytes	Easily isolated	Reduced potency
B cells	More robust numbers	Reduced generation of Tmem (26), increased production time
PHA blasts	Reduced production time, easily expanded	Moderate potency
Artificial APC	Easily expanded and maintained; effective costimulation	Varying efficacy