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. 2017 Jul 8;6(10):1103–1112. doi: 10.1016/j.molmet.2017.07.002

Figure 1.

Figure 1

Uncoupling of the melanocortin system with centrally administered DNP induced weight-loss, increased BAT thermogenesis and WAT browning. The weight loss induced by DNP was eliminated by pre-treatment with AgRP, and was absent in MC4KO mice. (A–C) Effects of ICV DNP administration on body weight, BAT temperature, and food intake compared to aCSF vehicle (n = 4–5 per group). (D) UCP1 mRNA expression in BAT and ingWAT depots after ICV DNP or vehicle injections. (E) ingWAT was unilaterally denervated prior to ICV DNP or vehicle injections. (F–H) Effects of ICV administration of DNP on body weight, BAT temperature and food intake, after pre-treatment with AgRP (n = 3–6 per group). (I–K) Effects of ICV administration of DNP on body weight, BAT temperature and food intake in MC4KO mice (n = 3 for all conditions). All data Mean ± SEM. *p < 0.05, **p < 0.01.