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. 2017 Oct 11;4:155. doi: 10.3389/fmed.2017.00155

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Copyright © 2017 Roux, Bendib Le Lan, Holifanjaniaina, Thomas, Picard, Grenet, De Miranda, Douvry, Beaumont-Azuar, Sage, Devaquet, Cuquemelle, Le Guen, Suberbielle, Gautreau, Stern, Rossetti, Hamid and Parquin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean fluorescence intensity (MFI) of immunodominant donor-specific antibody (DSA) at peak according to antibody-mediated rejection (AMR) status. Peak was defined as the time point of DSA with the highest sum MFI for AMR^Neg (DSA^PosAMR^Neg) patients, or as the time of AMR diagnosis for AMR^Pos patients. (A) Each patient’s immunodominant DSA is a circle. Circles inside broken line ellipse (n = 7) represent patients with AMR despite an immunodominant DSA MFI < 5,000, whose characteristics are detailed in panel (C) (Mann–Whitney test). (B) ROC curve for use of immunodominant DSA MFI as a predictor of AMR diagnosis, and the specificity/sensitivity according to different MFI cut-offs. (C) Characteristics of the 7 AMR^Pos patients with immunodominant DSA MFI < 5,000. Significance values are denoted above lines over compared groups.