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. 2017 Oct 11;4:155. doi: 10.3389/fmed.2017.00155

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Copyright © 2017 Roux, Bendib Le Lan, Holifanjaniaina, Thomas, Picard, Grenet, De Miranda, Douvry, Beaumont-Azuar, Sage, Devaquet, Cuquemelle, Le Guen, Suberbielle, Gautreau, Stern, Rossetti, Hamid and Parquin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DQ mean fluorescence intensity (MFI) of donor specific antibody (DSA) at peak according to antibody-mediated rejection (AMR) status. Peak was defined as the time point of DSA with the highest sum MFI for AMR^Neg (DSA^PosAMR^Neg) patients, or as the time of AMR diagnosis for AMR^Pos patients. (A) Frequency and number of patients with DQ DSA at the peak. (B) Frequency and number of patients with immunodominant DQ DSA at the peak. (C) Each patient’s DQ DSA MFI are represented as a circle. Comparison of number of patients, as well as median and mean DQ DSA MFI, for AMR^Pos and AMR^Neg patients is in the table below. (D) ROC curve for use of DQ DSA MFI as a predictor of AMR diagnosis and the specificity/sensitivity according to different MFI cutoffs. Groups were compared using Chi-square (A,B) and Mann–Whitney tests (C) and significance values are denoted above lines over compared groups.