Figure 5.

Clinical outcome associated with anti-HLA DQ donor-specific antibody (DQ DSA). Patients were categorized as DQ DSA if they had at least once DSA directed against one DQ antigen. Patients were categorized as non DQ DSA if they had DSA but never directed against DQ antigen. (A) Graft survival conditioned by 3-month survival compared between DSA negative, non-DQ DSA and DQ DSA patients. Global comparison was statistically significant, but non-DQ DSA and DQ DSA comparison did not reach significance. (B) CLAD occurrence between DSA negative, non-DQ DSA, and DQ DSA patients. Again, global comparison was statistically significant, but non-DQ DSA and DQ DSA comparison did not reach significance. (C) Graft survival conditioned by 3-month survival compared between non DQ DSA AMR^neg, DQ DSA AMR^neg, and DQ DSA AMR^pos patients. The only non-DQ DSA AMR^pos patient was exclude of the analysis. Both global and DQ DSA AMR^neg and DQ DSA AMR^pos comparison were highly significant.