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. Author manuscript; available in PMC: 2017 Oct 16.
Published in final edited form as: Biochemistry. 2017 Feb 16;56(8):1075–1084. doi: 10.1021/acs.biochem.6b00978

Figure 5.

Figure 5

BLIP-II hotspot residues for binding PBP2a (A) and class A β-lactamases (B). BLIP-II is shown in grey ribbon with hotspot residues shown as spheres. Red residues indicate a greater than 10-fold decrease in binding upon mutation to alanine and orange indicates at least a 5-fold decrease in binding upon mutation. The hotspot residues for the class A β-lactamases (B) are hotspots for all class A β-lactamases tested in Brown et. al.(13). A bullseye representation of BLIP-II binding hotspots is shown on the bottom half of the figure.