Figure 3.
R258W mutation in FFAR1 protects against HFD-induced glucose intolerance. (A and C) Blood glucose and (B and D) plasma insulin concentrations during ipGTT of wild-type (white symbols and bars) and Ffar1R258W/R258W littermates (black symbols and bars) after (A and B) CD and (C and D) HFD feeding expressed as means ± SEM, n = 4–6 (CD) and 6–8 (HFD) male mice. * denotes significance vs respective 0 min time point. # denotes significance between HFD and CD of wild-type mice at the same time point; § significance between genotypes at the same condition. (E) Blood glucose in wild-type (white symbols) and Ffar1R258W/R258W (black symbols) mice during ipITT after CD (triangles, n = 4–6) and HFD (circles, n = 6–8). (F) Body weight gain during high fat feeding.