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. 2017 Jul 18;6(10):1304–1312. doi: 10.1016/j.molmet.2017.07.007

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

R258W mutation of FFAR1 did not influence HFD-stimulation of adipocyte hormone release nor liver fat accumulation. Fasting plasma (A) leptin and (B) resistin concentrations after CD (n = 4–6) and HFD (n = 6–8) feeding of wild-type (white bars) and Ffar1^R258W/R258W mice (black bars). Liver fat droplets (red staining) in (C) wild-type and (D) Ffar1^R258W/R258W liver tissue sections counterstained with hematoxylin. Scale bars, 100 μm. (E) Mean hepatic TG of HFD fed wild-type (WT, white bar) and Ffar1^R258W/R258W (HO, black bar) mice. (F) Plasma glucose concentrations before (0 min) and 15 and 30 min after an oral glucose load (n = 6–8). Data are expressed as means ± SEM. *** denotes significance to the respective plasma concentration of CD fed mice; * significant to respective 0 min.