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. 2017 Jul 18;6(10):1264–1273. doi: 10.1016/j.molmet.2017.07.009

Figure 3.

Figure 3

iSIRT3 mice on HFD showed improved glucose homeostasis compared to S3fl mice. (A–B) Tail blood glucose values of insulin sensitivity test (IST) for S3fl and iSIRT3 mice on CD and HFD, respectively; (A) CD [n = 7–8; 2-way RM ANOVA (time × genotype)]. (B) HFD [n = 7–10; 2-way RM ANOVA (time × genotype) with Bonferroni's multiple comparisons post hoc test; time × genotype, P < 0.01; genotype effect at time point 90 min, ∗P < 0.05]. (C) Area above the curve (AAC) of IST curves in A [n = 7–8; Mann–Whitney test]. (D) AAC of IST curves in B [n = 7–10; Unpaired t test]. (E–F) Tail blood glucose values of oral glucose tolerance test (OGTT) for S3fl and iSIRT3 mice on CD and HFD respectively. (E) CD [n = 9–10; 2-way RM ANOVA (time × genotype)]. (F) HFD [n = 6–7; 2-way RM ANOVA (time × genotype) with Bonferroni's multiple comparisons post hoc test; time × genotype, P < 0.05; genotype effects at time point 30 min, ∗∗P < 0.01 and 60 min, ∗P < 0.05]. (G) Area under the curve (AUC) for OGTT curves in E [n = 9–10; Unpaired t test]. (H) AUC for OGTT curves in F [n = 6–7; Mann–Whitney test; genotype, ns]. Data are presented as mean values ± SEM.