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iSIRT3 mice showed a differentially regulated metabolic activity of jejunal enterocytes in response to an oral gavage of fatty acid. LC-MS analyses of metabolites from the duodenum, jejunum, and liver of S3fl and iSIRT3 mice after oleic acid gavage, represented as fold change compared to S3fl controls. (A) NAD+, (B) NADH, (C) ATP/ADP, (D) Palmitoyl CoA [n = 3–5; Mann–Whitney test, *p < 0.05]. Data are presented as mean values ± SEM.
