Effects of renal denervation on glycemia in male WT and db/db mice. A) Renal denervation improves glucose tolerance in 8–10-wk old WT mice; B) Elevated glycosuria in renal-denervated WT mice; C) No change in insulin sensitivity after renal denervation in WT mice; D) Renal denervation improves glucose tolerance in db/db mice; E) Elevated glycosuria in renal-denervated 9-wk old db/db mice; F) Reduced glycosuria in renal-denervated 12-wk old db/db mice. *P < 0.05, **P < 0.01, ***P < 0.001, 2-tailed Student's t-test or 2-way RMANOVA followed by Tukey's multiple comparison test was used for comparisons as appropriate; n = 6. RD, renal denervation; AUC, area under the curve. Error bars reflect mean ± SEM.