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. 2017 Sep 21;36(20):2928–2930. doi: 10.15252/embj.201798063

Figure 1. The role of the NMD factor UPF3B in aberrant translation termination.

Figure 1

In the context of normal translation termination, PABP (PolyA‐binding protein) facilitates recruitment of the release factors (eRF1/eRF3) to the pre‐TC. When translation termination is aberrant, ribosome stalling is further enhanced by the NMD factor UPF3B, which aids the recruitment of release factors and subsequently promotes ribosome release and the assembly of NMD factors. UPF2 antagonizes the UPF3B‐enhanced recruitment of the eRF1/eRF3 complex to the pre‐TC.