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. 2017 Aug 10;6(10):1173–1185. doi: 10.1016/j.molmet.2017.08.002

Figure 1.

Figure 1

Time course analysis of GLP-1R GFP and beta arrestin-1RFP association in context of the cyclic AMP generation on receptor activation: A. BRIN-BD11 pancreatic beta cells were transfected with GFP-tagged GLP-1R and Beta arrestin-1RFP, stimulated with 100 nM Exendin-4 for 1 min, 10 min, and 30 min, after which they are fixed and visualized by confocal microscopy. Images are representive of three independent experiments n = 15 cells/each time point B. Time course of GLP-1R mediated cyclic AMP generation on activation with Exendin-4 (n = 3). C. Time course of GLP-1R mediated cyclic AMP generation on activation with Liraglutide (10 nM), (n = 3). The data is expressed as mean ± SEM (*p < 0.05; **p < 0.01, n = 3).