Figure 6.

Inhibition of human α9α10 nAChR by linear GeXIVA and ribbon cGeXIVA isomers. A, bar graph of globular GeXIVA, bead GeXIVA, ribbon GeXIVA, ribbon cGeXIVA_G, ribbon cGeXIVA_GG, and ribbon cGeXIVA_GAG (100 nm) inhibition of ACh-evoked peak current amplitude mediated by hα9α10 nAChRs. Whole-cell hα9α10 nAChR-mediated currents were activated by 6 μm ACh. B, concentration–response curves of globular and ribbon GeXIVA and ribbon cGeXIVA_GG inhibition of ACh-evoked currents mediated by hα9α10 nAChRs (means ± S.E., n = 4–12).