Table 1.

Conditions tested for the chlorination reaction.^[a]

Entry	T [°C]	t r [min]	Yield 3 [b] [%]
1[c]	85	60	80
2[c]	100	60	100
3[c]	110	30	100
4[c]	125	15	70
5[c]	150	15	70
6[d]	100	30	100
7[d]	100	15	85

[a] See the Experimental Section for the reaction conditions. [b] Conversions were determined by ¹H NMR, after evaporation of the solvent. [c] Flow stream A: 2 (1 m) in toluene/DMF (9:1) containing 0.1 equiv imidazole; flow stream B: SOCl₂ in toluene (3 m). [d] Flow stream A: 2 in DMF containing 1 % imidazole; flow stream B: neat SOCl₂.