Table 1. Synergy of 600 Da BPEI and β-Lactams against MRSA 700787 and MSSA 25923a.
MICA (μg/mL)/μM |
MICB (μg/mL)/μM |
||||||
---|---|---|---|---|---|---|---|
strain | antibiotic | alone | comb. | alone | comb. | FICI | outcome |
MRSA 700787 | oxacillin | 64/149 | 4/9 | 4/6.6 | 0.5/0.8 | 0.188 | synergy |
0.5/1.1 | 1/1.6 | 0.258 | |||||
ampicillin | 128/345 | 8/22 | 4/6.6 | 0.5/0.8 | 0.188 | synergy | |
2/5 | 1/1.6 | 0.266 | |||||
amoxicillin | 128/305 | 8/22 | 4/6.6 | 1/1.6 | 0.313 | synergy | |
methicillin | 64/160 | 4/10 | 4/6.6 | 2/3.3 | 0.563 | additivity | |
meropenem | 2/4.6 | 0.5/1.1 | 4/6.6 | 0.5/0.8 | 0.375 | synergy | |
chloramphenicol | 8/25 | 2/6 | 4/6.6 | 1/1.6 | 0.500 | additivity | |
linezolid | 2/5.9 | 0.5/1.5 | 4/6.6 | 1/1.6 | 0.500 | additivity | |
vancomycin | 2/1.3 | 2/1.3 | 4/6.6 | 4/6.7 | 1.0 | no synergy | |
MSSA 25923 | oxacillin | 0.064/0.14 | 0.032/0.072 | 32/53 | 8/13 | 0.75 | additivity |
ampicillin | 0.064/0.17 | 0.032/0.086 | 32/53 | 8/13 | 0.75 | additivity | |
amoxicillin | 0.064/0.16 | 0.016/0.038 | 32/53 | 16/27 | 0.75 | additivity |
MICA is minimum inhibitory concentration of the antibiotic; MICB is minimum inhibitory concentration of BPEI; FICI is fractional inhibitory concentration index.