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. 2017 Sep 20;8(10):1083–1088. doi: 10.1021/acsmedchemlett.7b00285

Table 1. Synergy of 600 Da BPEI and β-Lactams against MRSA 700787 and MSSA 25923a.

    MICA (μg/mL)/μM
MICB (μg/mL)/μM
   
strain antibiotic alone comb. alone comb. FICI outcome
MRSA 700787 oxacillin 64/149 4/9 4/6.6 0.5/0.8 0.188 synergy
    0.5/1.1   1/1.6 0.258  
ampicillin 128/345 8/22 4/6.6 0.5/0.8 0.188 synergy
    2/5   1/1.6 0.266  
amoxicillin 128/305 8/22 4/6.6 1/1.6 0.313 synergy
methicillin 64/160 4/10 4/6.6 2/3.3 0.563 additivity
meropenem 2/4.6 0.5/1.1 4/6.6 0.5/0.8 0.375 synergy
chloramphenicol 8/25 2/6 4/6.6 1/1.6 0.500 additivity
linezolid 2/5.9 0.5/1.5 4/6.6 1/1.6 0.500 additivity
vancomycin 2/1.3 2/1.3 4/6.6 4/6.7 1.0 no synergy
MSSA 25923 oxacillin 0.064/0.14 0.032/0.072 32/53 8/13 0.75 additivity
ampicillin 0.064/0.17 0.032/0.086 32/53 8/13 0.75 additivity
amoxicillin 0.064/0.16 0.016/0.038 32/53 16/27 0.75 additivity
a

MICA is minimum inhibitory concentration of the antibiotic; MICB is minimum inhibitory concentration of BPEI; FICI is fractional inhibitory concentration index.