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Conjugate 6 shows potent protein knockdown activity. K562 cells were incubated with the indicated concentration of conjugates 5, 6, or ligand mix (ABL ligand 2 or 3 plus IAP ligand 4) for 6 h. Numbers below the ABL panel represent the BCR-ABL/β-actin ratio normalized by the vehicle control as 100. Data in the bar graph are means ± standard deviation (n = 3).
