Table 2. In Vitro and in Vivo PK Parameters of 13 (IDH305).

PK parameter	mouse	rat	dog	human
in vitro liver microsomal Clint (μL min–1 mg–1)	61	45	28	56
in vitro predicted liver microsomal Cl (mL min–1 kg–1)	65	33	18	14
in vivo plasma clearance (mL min–1 kg–1)	29	34	24	n.d.a
plasma protein binding (%)	88	83	89	83
brain homogenate binding (%)	93	95	n.d.	n.d.
brain to plasma ratio (total/unbound)	0.29/0.17	0.61/0.18	n.d.	n.d.

^an.d., not determined