Table 1.

NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk

	Alleles		Minor Allele Frequency			Case Allele Counts		Control Allele Counts		Association
	Minor	Major	All	Cases	Controls	A1	A2	A1	A2	p	OR	Cochran’s Q	I2
Denmark	A	G	0.00020	0	0.00040	0	2,534	1	2,475	0.375	–	–	–
Germany	A	G	0.00025	0	0.00026	2	8,950	3	11,425	0.845	–	–	–
Italy	A	G	0.00048	0.00065	0.00032	2	3,058	1	3,161	0.677	–	–	–
Netherlands	A	G	0.00042	0.00087	0.00028	1	1,151	1	3,609	0.317	–	–	–
Norway	A	G	0.00116	0.00127	0.00098	2	1,572	1	1,015	0.822	–	–	–
Sweden	A	G	0.00041	0.00053	0.00027	7	13,139	3	10,989	0.331	–	–	–
UK/Austrailia	A	G	0.00060	0.00054	0.00064	9	16,559	15	23,263	0.963	–	–	–
USA/Boston	A	G	0.00050	0.00042	0.00060	5	11,931	6	10,046	0.955	–	–	–
USA/UCSF	A	G	0.00048	0.00083	0.00000	3	3,627	0	2,660	0.127	–	–	–
Meta-analysis	A	G	–	–	–	31	–	31	–	0.3293	1.064	0.825	0

We meta-analyzed 32,852 cases and 36,538 controls of European ancestry in 14 country-level strata using linear mixed models to control for stratification. We detected the minor allele rs61731956-A in nine of our strata, but find no evidence of association to overall MS risk.