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. Author manuscript; available in PMC: 2017 Oct 16.
Published in final edited form as: Neuron. 2016 Oct 19;92(2):333–335. doi: 10.1016/j.neuron.2016.09.052

Table 2.

NR1H3 p.Arg415Gln Is Not Associated to MS Clinical Course

Frequency in PPMS Cases Effect size (β) Standard Error p Cochran’s Q I2
Italy 0 Na – – – –
Netherlands 0 Na – – – –
Norway 0.0013 −0.08 0.19 0.66 – –
Sweden 0.0006 0.09 0.09 0.34 – –
UK/Australia 0.0007 0.11 0.11 0.34 – –
USA/UCSF 0.0012 −0.08 0.17 0.65 – –
Meta-analysis – 2.32 – 0.39 0.69 0

We compared 1,399 PPMS cases and 13,537 RRMS cases directly in six strata with available clinical course information and also find no evidence of association between rs61731956-A and clinical subtype.