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. Author manuscript; available in PMC: 2017 Oct 16.
Published in final edited form as: J Neuroimmune Pharmacol. 2016 May 6;11(3):592–600. doi: 10.1007/s11481-016-9682-9

Fig. 4.

Fig. 4

Variant neuropathological changes and CD4/CD8 ratio over time in CP macaques a–d. ISH for SIV RNA (BCIP/NBT; indigo) in brains of CP macaques. More SIV-expressing cells presented in the brain of WSL03 (a, temporal cortex) and WSP10 (b, occipital cortex) comparing to WSP08 (c, occipital cortex) and WSP11 (d, cerebellum). e–h. Distribution of CD68+ macrophages (DAB; brown) in brains of CP macaques with SIVmac239 infection. e. CD68+ macrophage accumulation was seen in the cerebellum of WSL03. f. CD68+ macrophages scattered in the brain of WSP10. g–h. IHC staining of CD68 was not significant in the brain of WSP08 (g) and WSP11 (h), while ISH for SIV-RNA was positive (c and d). i. CD4/CD8 ratio in 5 CP macaques with a neuropathological diagnosis. Scale bars: 50 μm